Dr Kevin J. Saliba
Position
Senior Lecturer, ANU Medical School
Contact
Biochemistry and Molecular Biology
School of Biology
College of Medicine, Biology and Environment
The Australian National University
Canberra, ACT, 0200
Tel: (02) 61257549
Fax: (02) 61250313
E-mail: kevin.saliba@anu.edu.au
Web:www.anu.edu.au/bambi/people/academic/saliba.php
Research interests
Our work aims to identify and characterise physiological and biochemical pathways in the intraerythrocytic stage of the human malaria parasite Plasmodium falciparum which may be utilised as targets for antimalarial chemotherapy. Pathways under investigation include coenzyme A biosynthesis and pH regulation.
Qualifications
BSc 1991
BSc (Med) (Hons) 1992
PhD (Cape Town) 1997
Ten Most Significant Publications
Saliba, K.J., Folb, P.I. and Smith, P.J. (1998) Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance. Biochemical Pharmacology 56:313-320
Saliba, K.J., Horner, H.A. and Kirk, K. (1998) Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Journal of Biological Chemistry 273:10190-10195
Saliba, K.J. and Kirk, K. (1999) pH regulation in the intracellular malaria parasite, Plasmodium falciparum: H+ extrusion via a V-type H+-ATPase, Journal of Biological Chemistry 274:33213-33219
Reed, M.B., Saliba, K.J., Caruana, S.R., Kirk, K. and Cowman, A.F. (2000) Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum, Nature 403:906-909
Saliba, K.J. and Kirk, K. (2001) H+ coupled pantothenate transport in the intracellular malaria parasite, Plasmodium falciparum. Journal of Biological Chemistr y 276:18115-18121
Saliba, K.J., Allen, R.J.W., Zissis, S., Bray, P.G., Ward, S.A. and Kirk, K. (2003) Acidification of the Malaria Parasite’s Digestive Vacuole by a H -ATPase and a H –pyrophosphatase. Journal of Biological Chemistry 278:5605-5612
Hayward, R., Saliba, K.J. and Kirk, K. (2006) The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance, Journal of Cell Science 119:1016-1025
Saliba, K.J., Martin, R.E., Bröer, A., Henry, R.I., McCarthy, C.S., Downie, M.J., Allen, R.J.W., Mullin, K.A., McFadden, G.I., Bröer, S. and Kirk, K. (2006) Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature 443:582-585
Lehane, A.M., Marchetti, R.V., Spry, C., van Schalkwyk, D.A., Teng, R., Kirk K. and Saliba, K.J. Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite. The Journal of Biological Chemistry 282:25395-25405
van Schalkwyk, D.A., Priebe, W. and Saliba, K.J. (2008) The inhibitory effect of 2-halo derivatives of D-glucose on glycolysis and on the proliferation of the human malaria parasite Plasmodium falciparum. Journal of Pharmacology and Experimental Therapeutics 327:511-517.
Currently Held Grants
ARC Discovery Grant: Kirk, K. and Saliba, K.J. 2007-2009 'Ion transport in the malaria parasite and parasitised erythrocyte'
ACT Health Grant: Saliba, K.J. 2008/2009 'Riboflavin utilisation by malaria parasites as an antimalarial drug target'
Go8-DAAD Grant: Saliba, K.J. and Wrenger, C. 2009 'Vitamin B1 acquisition by the human malaria parasite Plasmodium falciparum' |
