The Australian Society for Parasitology Inc.
POSITION NO 0041443
This position will be offered at either PSC 5 or 6, based on the candidates application, qualifications and experience.
PSC 5 : $66,562 – $76,454 p.a.
PSC 6 : $77,207 – $88,573 p.a.
Employer contribution of 17%
Full-time continuing position
HOW TO APPLY
Online applications are preferred. Go to http://about.unimelb.edu.au/careers, under ‘Job Search and Job Alerts’, select the relevant option (‘Current Staff’ or
‘Prospective Staff’), then find the position by title or number.
CONTACT FOR ENQUIRIES ONLY
Dr Abdul Jabbar
Tel +61 3 9731 2022
Please do not send your application to this contact
Upon entry into liver-stages, P. vivax sporozoites take two distinct developmental pathways with some directly developing in tissue schizonts that cause blood infections within 10-12 days, while others become ‘dormant’ hypnozoites, that remain developmentally arrested before reactivating weeks or months later to cause relapsing blood-stage infections. While the processes that govern this developmental switch are unknown, it is likely that the switch is pre-determined in sporozoites. We have started to analyses sporozoite transcriptional, translational and epigenetic patterns to identify potential makers for the developmental fate of sporozoites. Once sporozoites enter a human hepatocyte, they need to keep their cell alive long enough to complete their development. For hypnozoites, this means preventing host cell adoptosis for up to 2-3 years. In our preliminary studies, we have identified a number of highly expressed sporozoites proteins that may be interfering with the host apoptotic system. We now want to extend these studies in two direction: i) single cell transcriptomic analyses of P. vivax sporozoites and ii) screening sporozoites mRNA for proteins that interfere with apoptosis in human hepatocytes.
The Post-doctoral Fellow will be responsible for establishing the required laboratory and bioinformatics protocols for the transcriptomic analyses of field samples. In particular, s/he will be responsible for establishing single cell protocols (based on FACS sorting and/or DropSeq technologies) for transcriptomic analyses of individual sporozoites that were preserved at endemic sites in the Asia-Pacifc. This part of the project will be done in collaboration with researchers in the Jex Lab and Sequencing Platform at WEHI. In addition, the post-doc will work collaboratively with specialist in human apoptosis (Huang Lab, Cancer and Haemtology Division) to produce a lentiviral cDNA library from P. vivax sporozoites mRNA and screen this library for anti-apoptotic activity in human hepatocytes. The position will require close collaboration with endemic country scientist including the mentoring of PhD and MSc students and a willingness to spend time working in the endemic countries.
Candidates should have a PhD in molecular parasitology or systems biology, with a solid knowledge of genomic, transcriptomic and/or analyses (DNA/RNAseq/ChIPseq and bioinformatics analyses).
The position will require a high degree of self-motivation and ability to work independently as well as a willingness to work in international collaborative environment (incl. spending time in malaria endemic countries and/or overseas laboratory). Previous experience in malaria or other tropical infectious diseases, single cell methodologies or high throughput screening would be beneficial but not a requirement.
This position is available for 2 years (with potential extension) starting in the last quarter of 2016 or 1st quarter of 2017. Salary is dependent on qualifications and experience. Up to 17% superannuation and attractive salary packaging options are available.
A position description is available at http://www.wehi.edu.au/senior-research-officer-postdoctoral-scientist
General enquiries can be directed to Professor Ivo Mueller- email@example.com
Applications should include a Cover Letter, CV and the names of 3 professional referees emailed in pdf format to firstname.lastname@example.org quoting reference WEHI/CAIM in the subject line.
Application closing date: Sunday 23 October 2016
At the Walter and Eliza Hall Institute, we strive to ensure our staff and students enjoy a great working environment. We value diversity and gender equity in our workforce and promote flexible working arrangements for staff to balance working requirements and personal needs.
The APVMA is responsible for the assessment and registration of agricultural and veterinary chemicals and for their regulation up to and including the point of sale. This position is in the Registration Management and Evaluation Program which is responsible for registering agricultural and veterinary chemical products.
The role of a Senior Risk Manager in the Veterinary Medicines Section is to evaluate the safety, efficacy and trade aspects of veterinary chemical products within agreed timeframes. As a Senior Risk Manager, you will apply your scientific knowledge, risk management skills and project management skills to complete determinations of the registration of veterinary medicines within statutory timeframes. You will have management responsibilities involving staff supervision and will maintain strong working relationships with internal and external stakeholders to achieve the Program’s goals.
Please visit the APVMA eRecruitment portal to view the full position description, selection criteria and apply online – https://careers.apvma.gov.au/
Position Contact: Angela O’Sullivan
The Australian Institute of Tropical Health and Medicine (AITHM) is a newly established health research institute within James Cook University, Australia. AITHM’s focus is on research in tropical health and medicine across a wide range of disciplines.
An opportunity exists for a postdoctoral position in the molecular immunology of infectious and chronic diseases, including malaria. A specific interest is the application of systems immunology to explore the mechanisms underlying immune responsiveness and vaccine efficacy, using samples from humans experimentally infected with Plasmodium parasites in controlled human malaria infections, or naturally exposed to malaria in geographically distinct field sites; as well as humans experimentally or naturally infected exposed to, or vaccinated against, other infectious and chronic diseases. A related interest is on omic-based technologies and rational vaccine design. An underlying concept is that development of optimally efficacious interventions against chronic infectious diseases such as malaria will need to improve on nature, and this can be accomplished by mining large-scale omic datasets to identify molecules and mechanisms underlying protective immunity. It is anticipated that this research will have broad application to a wide range of infectious and chronic diseases, with important implications for vaccination.
Additional Details & Application:
Tel: 61 430 589 981
www.jcu.edu.au (Position # 6000013514)
Are you interested in vector ecology and next generation sequencing techniques? Would you like to learn advanced molecular techniques in a vibrant research group at Murdoch University? Our group is investigating potentially pathogenic microorganisms in ticks as part of an ARC-funded project entitled “Tiresome ticks: Ecology and transmission of tick-borne disease in Australia”. We are looking for a motivated and enthusiastic PhD student to be involved with every aspect of this highly relevant and exciting research. Some background in next generation sequencing is desirable.
A stipend of $27K is available to Australian citizens and permanent resident applicants. Please contact Professor Peter Irwin (P.Irwin@murdoch.edu.au) for more information.
Area of study: The Plasmodium cycle in its mosquito vector
For more information:
Johns Hopkins School of Public Health
Malaria Research Institute
Baltimore, Maryland, USA
Send CV and names of three references to email@example.com