Background New opportunities to join a highly productive laboratory focused on developing new approaches for studying host-pathogen interactions at the molecular level. The human pathogen Toxoplasma gondii enjoys excellent forward and reverse genetic tools as well as animal models, making it an attractive model for studying host-pathogen interactions. Projects offer potential for independent career advancement and are supported by excellent core facilities for animal studies, biological imaging, genomics, and immunological profiling.
Project 1: Develop small animal models for chronic infection with Toxoplasma gondii as a platform to explore genetic determinants of pathogenesis and regulation of host immunity (Ann. Rev. Micro. 2016, 70: 63-81). Prior experience with immunology, microbiology, and molecular biology are highly desirable.
Project 2: Utilize biochemical analysis of protein complexes and reverse genetic strategies to define the molecular basis of a novel parasite effector that blocks interferon signaling in human cells (Cell Host Microbe 2016, 20: 72-82). Prior experience with molecular genetics, biochemical analysis of protein interactions, and analysis of genome-wide datasets are highly desirable.
Project 3: Discover new pathogenesis determinants by combining CRISPR/Cas9 mediated screening with reverse genetics to define the molecular basis of pathogenesis (Methods Molec. Biol. 2017: 1498, 79-103). Prior experience with molecular genetics, comparative genomics, and analysis of genome-wide datasets are highly desirable.
Criteria Recent Ph.D. in Microbiology, Immunology, or Molecular Biology. Good command of the English language (speaking and writing), analytical, and computational skills are considered essential.
Benefits Washington University offers a highly diverse intellectual community with outstanding training opportunities for postdoctoral fellows. Salary and benefits along with educational and training opportunities are summarized at the Office of Post Graduate Affairs. See http://dbbs.wustl.edu/PostDocs/Pages/PostDocs.aspx
How to apply Submit a current C.V. and names of three references to:
Dr. David Sibley, Professor, (firstname.lastname@example.org), Dept. Molecular Microbiology, Washington University Sch. Med., St. Louis, MO 63110.
Background: The Malaria Programme at the Wellcome Trust Sanger Institute has recently achieved major breakthroughs in scaling reverse genetic screening for the systematic identification of gene functions in Plasmodium. The Institute is also a leading centre for single cell genomics.
Position: We are now looking to recruit a 3-year Postdoctoral Research Fellow to work on an exciting project to bridge these areas. If you have recently received your PhD, have a passion for parasite biology and genetics and are interested in working with large datasets we would like to hear from you! The project offers an opportunity to combine our recently developed screening platform with state-of-the-art single cell phenotyping by transcriptomics. By bringing these approaches together you will be able to generate deep new insights into fascinating aspects of parasite biology, including sexual development, and host parasite interactions. This position will work between the Billker team in the Malaria Programme and the Cellular Genetics Programme led by Sarah Teichmann. It will offer training opportunities in both wet lab and computational areas, but the wet lab component will be essential.
Further information: For more details about the position and our research, visit our laboratory website (www.sanger.ac.uk/science/groups/billkergroup) or contact Oliver Billker (email@example.com)
How to apply: https://jobs.sanger.ac.uk
Are you interested in vector ecology and next generation sequencing techniques? Would you like to learn advanced molecular techniques in a vibrant research group at Murdoch University? Our group is investigating potentially pathogenic microorganisms in ticks as part of an ARC-funded project entitled “Tiresome ticks: Ecology and transmission of tick-borne disease in Australia”. We are looking for a motivated and enthusiastic PhD student to be involved with every aspect of this highly relevant and exciting research. Some background in next generation sequencing is desirable.
A stipend of $27K is available to Australian citizens and permanent resident applicants. Please contact Professor Peter Irwin (P.Irwin@murdoch.edu.au) for more information.