Title Postdoctoral Research position
Location The Lindsley F. Kimball Research Institute of the New York Blood Center
Job Information

Postdoctoral Research position available immediately at The Lindsley F. Kimball Research Institute of the New York Blood Center, Laboratory of Molecular Parasitology

 

We are seeking candidates for a postdoctoral position in immunology and vaccinology. The research fellow or staff scientist will be involved in projects that center on the identification and characterizing of immunomodulatory and/or immunostimulatory proteins naturally secreted by the filarial parasites Onchocerca volvulus and Brugia malayi with the ultimate goal of defining their mode of action and developing them as biologics for human use.

Another aspect of the research is to continue studying the mechanism of action of the O. volvulus protein Ov-ASP-1, which has intrinsic immunostimulatory properties and can be used as a powerful immunostimulatory adjuvant; it promotes a balanced Th1/Th2 antibody response and cellular responses to several soluble bystander vaccine antigens and commercial inactivated viral vaccines, including the trivalent-inactivated flu vaccines. The objective of this study is to develop this highly effective and safe protein adjuvant for use in varied vaccines in a simple aqueous formulation and a much lower dose of the bystander vaccine antigen. By enhancing vaccine efficacy, we can effectively increase the number of vaccine doses available that can be administered to humans to boost their protective immune response against pathogens. The research project has therefore a translational implication for the prevention of various infectious diseases. The mechanisms of action of this adjuvant in synergy with other adjuvants is also been studied.

Applicants should have a PhD and/or MD with extensive experience and knowledge of the human and mouse innate and adaptive immunity, system biology, vaccinology, and mode of actions of vaccines and immunomodulatory and/or immunostimulatory molecules or proteins, with an interest in the translational aspects of these research disciplines. Some experience in molecular techniques, bioinformatics and the use of experimental animal models is also required. Excellent analytical and communication skills and a drive to independently ask and test scientific hypotheses are crucial. The appointed person is expected to be productive, creative, self-motivated with a good track record in the broader discipline of immunology with practical knowledge in cellular and molecular immunological techniques, be able to work efficiently, carefully organize experiments, and work as a member of a team.

We offer a competitive salary and a comprehensive benefit package. The New York Blood Center is an Equal Opportunity Employer. The title of the position will be decided based on the qualification of the appointed person.

The Lindsley F. Kimball Research Institute is a multi-disciplinary biomedical research institute with about 70 scientists in 18 independent laboratories (http://www.nybloodcenter.org/products-services/kimball-research-institute). The Institute is located within 2 blocks of Rockefeller University, Weill Cornell Medical College, and the Memorial Sloan Kettering Institute.

Interested applicants should send Curriculum vitae, statement of interest and the names, addresses and Telephone/E-mails of three references to:

Sara Lustigman, Ph.D.,

Head, Laboratory of Molecular Parasitology

Member, Lindsley F. Kimball Research Institute, New York Blood Center

310 East 67th St., New York, NY 10065, USA

Phone 212-570-3119; E-mail: slustigman@nybc.org

http://www.nybloodcenter.org/products-services/kimball-research-institute/sara-lustigman-phd/

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