Associate Professor Brian M. Cooke

Position

NHMRC Senior Research Fellow/Associate Professor

Contact

Department of Microbiology, Building 76
School of Biomedical Sciences
Monash University
Victoria 3800, Australia
Tel:+61-3-9902-9146
Fax:+61-3-9902-9222
Email: brian.cooke@med.monash.edu.au

Research interests

malaria, haemoprotozoa, babesia, red blood cells, molecular biology, cell biology, cell adhesion, cell mechanics, haemorheology

Qualifications

1993 University of Birmingham, UK Ph.D.
1989 UWE, Bristol, UK B.Sc. (Hons.)

Ten Most Significant Publications

1. Hutchings, C.L., Li, A., Fernandez, K.M., Fletcher, T., Jackson, L.A., Molloy, J.B., Jorgensen, W.K., Lim C.T. and Cooke, B.M. 2007. New insights into the altered adhesive and mechanical properties of red blood cells parasitized by Babesia bovis. Molecular Microbiology. 65, 1092-1105.

2. Cooke, B.M., Buckingham, D.W., Glenister, F.K., Fernandez, K.M., Bannister L.H., Marti, M., Mohandas, N. and Coppel, R.L. 2006. A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells. Journal of Cell Biology, 172, 899-908.

3. Cooke, B.M., Glenister, F. K., Mohandas, N., Coppel, R. L. 2002. Assignment of functional roles to parasite proteins in malaria-infected red blood cells by competitive flow-based adhesion assay. British Journal of Haematology, 117, 203-11.

4. Glenister, F.K., Coppel, R.L., Cowman, A.F., Mohandas, N., & Cooke, B.M. 2002. Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells. Blood, 99, 1060-1063.

5. Waterkeyn, J. G., Wickham, M. E., Davern, K. M., Cooke, B. M, Coppel, R. L., Reeder, J. C., Culvenor, J. G.,Waller, R. F., Cowman, A. F. 2000. Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells. EMBO Journal, 19, 2813-23.

6. Beeson, J. G, Rogerson, S. J., Cooke, B.M., Reeder, J. C., Chai, W., Lawson, A. M., Molyneux, M. E., Brown, G. V. 2000. Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria. Nature Medicine, 6, 86-90.

7. Waller, K. L., Cooke, B.M., Nunomura, W., Mohandas, N., Coppel, R. L. 1999. Mapping the binding domains involved in the interaction between the Plasmodium falciparum knob-associated histidine-rich protein (KAHRP) and the cytoadherence ligand P. falciparum erythrocyte membrane protein 1 (PfEMP1). Journal of Biological Chemistry, 274, 23808-13.

8. Cooke, B.M., Nicoll, C.L., Baruch, D.I. & Coppel, R.L. 1998. A recombinant peptide based on PfEMP1 blocks and reverses adhesion of malaria-infected red blood cells to CD36 under flow. Molecular Microbiology, 30, 83-90.

9. Crabb, B.S., Cooke, B.M., Reeder, J.C., Waller, R.F., Caruana, S.R., Davern, K.M., Wickham, M.E., Brown, G.V., Coppel, R.L. & Cowman, A.F. 1997. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell, 89, 287-296.

10. Cooke, B.M., Rogerson, S. J., Brown, G. V., Coppel, R. L. 1996. Adhesion of malaria-infected red blood cells to chondroitin sulfate A under flow conditions. Blood, 88, 4040-4.

Currently Held Grants

NHMRC Senior Research Fellowship. BM Cooke. 2009-2013

NHMRC Program Grant. 'Malaria: from bioinformatics to therapy'. CI's: RL Coppel, BM Cooke, M. Plebanski & M. von Itzstein. 2005-2009.

National Institutes of Health (USA). RO1. 'Adherence of malaria-infected red cells'. PI AF Cowman (co-investigators BM Cooke and RL Coppel). 2006-2010.