Position

Senior Research Fellow / Lab Head
NHMRC R D Wright Fellow
Immunology and Infection Laboratory,
The Queensland Institute of Medical Research

Research interests

• Immunopathology related to protozoan parasitic infections.
• Immune regulation in response to protozoan parasitic infections.
• Defining host immune responses to Leishmania donovani and Plasmodium berghei ANKA.
• Understanding immune regulation during parasitic co-infections.

Qualifications

PhD (1993, La Trobe University)

Ten Most Significant Publications

1. Engwerda, C. R., B. S. Handwerger, and B. S. Fox. 1994. Aged T cells are hyporesponsive to costimulation mediated by CD28. J Immunol 152:3740.

2. Engwerda, C. R., M. L. Murphy, S. E. Cotterell, S. C. Smelt, and P. M. Kaye. 1998. Neutralization of IL-12 demonstrates the existence of discrete organ- specific phases in the control of Leishmania donovani. Eur J Immunol 28:669.

3. Mynott, T. L., A. Ladhams, P. Scarmato, and C. R. Engwerda. 1999. Bromelain, from pineapple stems, proteolytically blocks activation of extracellular regulated kinase-2 in T cells. J Immunol 163:2568.

4. Engwerda, C. R., and P. M. Kaye. 2000. Organ-specific immune responses associated with infectious disease. Immunol Today 21:73.

5. Alexander, C. E., P. M. Kaye, and C. R. Engwerda. 2001. A role for CD95 in the control of murine visceral leishmaniasis caused by Leishmania donovani. Eur J Immunol 31:1199.

6. Engwerda, C. R., M. Ato, S. E. J. Cotterell, A. Tschannerl, P. Gorak-Stolinska and P. M. Kaye. 2002. Remodelling of the splenic marginal zone during Leishmania donovani .αinfection is mediated by TNF Am J Path 161:429.

7. Engwerda, C. R., T. L. Mynott, S. Sawhney, J. B. De Souza, ,alphaQ. Bickle and P. M. Kaye. 2002. Lymphotoxin- , is the α-not Tumor Necrosis Factor- principle mediator in murine cerebral malaria. J Exp Med 195:1371.

8. Ato, M., S. Stager, C. R. Engwerda, and P. M. Kaye. 2002. Defective CCR7-dependent migration of dendritic cells contributes to the development of chronic visceral leishmanisis. Nature Immunology 3:1185.

9. DeWalick, S., F. H. Amante, L. M. Randall, Y, Zhou, K. P. A. MacDonald, G. R. Hill and C. R. Engwerda. 2007. Cutting Edge: Conventional dendritic cells, but not plasmacytoid dendritic cells, mediate experimental cerebral malaria caused by Plasmodium berghei ANKA. J. Immunol. 178: 6033-6037.

10. Amante, F. H., A. C. Stanley, L. M. Randall, Y. Zhou, A. P. Waters, C. J. Janse, M. F. Good, G. R. Hill and C. R. Engwerda. 2007. A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria. Am. J. Path. 171: 548-549.

Currently Held Grants

1. NHMRC Project Grant (2006-2008). The role of TNF family members in visceral leishmaniasis. C. R. Engwerda, Kaye, P. M. and Ato, M.

2. NHMRC Program Grant (2008-2012). Immunity and pathogenesis in Tropical and Infectious Diseases. D. J. Kemp, Good, M.F., Sriprikash, S., Toth, I., McManus, D., Anstey, N., Doolan, D., Loukas, A.

3. Sarantis Ltd. Commercial Research Grant (2006-2008). Characterising the Immunomodulatory Properties of Proteases from Pineapple Stems. C. R. Engwerda.

4. Sarantis Ltd. Commercial Research Grant (2008). Characterising the Immunomodulatory Properties of Proteases from Bromelain II. C. R. Engwerda.