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Position
Pfizer Australia Senior Research Fellow
Head, Molecular Vaccinology Laboratory, The Queensland Institute of Medical Research
Contact
The Queensland Institute of Medical Research
The Bancroft Centre
Courier address: 300 Herston Road, Herston QLD 4006
Mailing address: PO Royal Brisbane Hospital, Brisbane QLD 4029
Australia
Tel: 61-7-3362 0382
Fax: 61-7-3362 0105
URL: www.qimr.edu.au/research/labs/denised/index.html
Research interests
The focus of the Molecular Vaccinology laboratory is on understanding the molecular basis of immunity to malaria and identifying the antigenic targets of this immunity, with the ultimate aim of developing a malaria vaccine.
Qualifications
PhD, MPhil, BSc(hons)
Ten Most Significant Publications
1. Doolan DL, Sedegah M, Hedstrom RC, Hobart P, Charoenvit Y, and Hoffman SL. 1996. Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity. J Exp Med. Apr 1. 183(4):1739-46.
2. Doolan DL, Hedstrom RC, Rogers WO, Charoenvit Y, Rogers M, de la Vega P, and Hoffman SL. 1996. Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum exported protein 1. J Biol Chem. Jul 26. 271(30):17861-68.
3. Doolan DL, Hoffman SL, Southwood S, Wentworth PA, Sidney J, Chesnut RW, Keogh E, Appella E, Nutman TB, Lal AA, Gordon DM, Oloo A, and Sette A. 1997. Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity. Jul. 7(1):97-112.
4. Doolan DL#, Wang R#, Le TP, Hedstrom RC, Coonan KM, Charoenvit Y, Jones TR, Hobart P, Margalith M, Ng J, Weiss WR, Sedegah M, de Taisne C, Norman JA, and Hoffman SL. 1998. Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. #co-first author. Science. Oct 16. 282(5388):476-80.
5. Doolan DL and Hoffman SL. 1999. IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. J Immunol. Jul 15. 163(2):884-92.
6. Doolan DL, Southwood S, Chesnut R, Appella E, Gomez E, Richards A, Higashimoto YI, Maewal A, Sidney J, Gramzinski RA, Mason C, Koech D, Hoffman SL, and Sette A. 2000. HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles. J Immunol. Jul 15. 165(2):1123-37.
7. Doolan DL and Hoffman SL. 2000. The complexity of protective immunity against liver-stage malaria. J Immunol. Aug 1. 165(3):1453-62.
8. Hoffman SL and Doolan DL. 2000. Malaria vaccines - targeting infected hepatocytes. Nat Med. Nov. 6(11):1218-19.
9. Doolan DL, Southwood S, Freilich DA, Sidney J, Graber NL, Shatney L, Bebris L, Florens L, Dobaņo C, Witney AA, Appella E, Hoffman SL, Yates JR 3rd, Carucci DJ, and Sette A. 2003. Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data. Proc Natl Acad Sci USA. Aug 19. 100(17):9952-57. Epub 2003 Jul 28.
10. Doolan DL, Mu Y, Hirst S, Verma S, Randal A, Blair PL, Aguair JC, Freilich DA, Baldi P, Davies DH, and Felgner PL. 2006. Profiling the humoral immune response to Plasmodium falciparum infection in humans using proteome microarray chips. Proteomics. Nov;8(22):4680-94. Epub 2008 Oct 20.
Currently Held Grants
NHMRC Project Grant #552423 (AUSTRALIA)
Period of Award: 01/01/09 - 31/12/2011
Role: Chief Investigator A
Title: Application of protein microarrays to develop a cross-species malaria vaccine
NHMRC Program Grant #496600 (AUSTRALIA)
Period of Award: 01/01/08 - 31/12/2012
Role: Chief Investigator G
Title: Immunity and pathogenesis in tropical and Infectious diseases: implications for vaccine development
Goal: To characterize host immunity to the Plasmodium parasite on a molecular level
Pfizer Australia Senior Research Fellowship (AUSTRALIA)
Period of Award: 01/7/2007 - 30/06/2012
Role: Principal Investigator
Title: Plasmodium falciparum immunomics: molecular immunological profiling of host immunity to malaria
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