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Professor Don P McManus

Position

Lab Head and Professor, QIMR

Contact

Professor Don McManus BSc, PhD, DSc,
Head, Molecular Parasitology Laboratory,
Queensland Institute of Medical Research
The Bancroft Centre,
300 Herston Road, Brisbane, QLD, 4006,
Tel: 61-7-3362 0401
Fax: 61-7-3362 0104
E-mail: donM@qimr.edu.au
http://www.qimr.edu.au

Research interests

Our laboratory researches the biology and epidemiology of parasitic worms of humans and the diseases they cause, particularly echinococcosis and schistosomiasis, and works on developing new interventions and diagnostic procedures that will lead to their elimination.

Qualifications

BSc, PhD, DSc

Ten Most Significant Publications

Ross, A.G., Vickers, D., Olds, R.G., Shah, S.M. and McManus, D.P. (2007). Katayama syndrome. Lancet Infectious Diseases 7: 218-224. IF: 10.01.

Craig, P.S. McManus, D.P., Lightowlers, M.W., Chabalogoity, J.A., Garcia, H.H., Gavidia, C.M., Gilman, R.H., Gonzalez, A.E., Lorca, M., Naquira, C/. Nieto, A., and Schantz, P.M.Cystic hydatid disease - new approaches to prevention and control. Lancet Infectious Diseases (in press). (Accepted 30th March, 2007). IF: 10.01.

Ross, A.G., Bartley, J., Sleigh, A.C., Olds, G.R., Li, Y.S., Williams, G.M. and McManus, D.P. (2002) Schistosomiasis. New England Journal of Medicine, 346: 1212-1220. IF: 44.0

Hu, W., Yan, Q., Shen, D-K., Liu, F., Zhu, Z-D., Song, H-D., Wang, Z-J., Rong, Y-P., Zeng, L-C., Wu, J., Zhang, X., Wang, J-J., Xu,X-N., Wang, S-Y., Fu, G., Xu, X-R., Zhang, X-L., Wang, Z-Q., Brindley, P.J., McManus, D.P., Xue, C-L., Zheng, F., Chen, Z. and Han, Z-G. Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource. Nature Genetics, 35: 139-147, Epub 2003 Sep 14. IF: 26.0

Thompson, R.C.A and McManus D.P. (2002). Towards a taxonomic revision of Echinococcus. Trends in Parasitology, 18: 452-457. IF: 4.5

Liu, F., Lu, J., Hu, W., Wang, S-Y., Cui, S-J., Chi,, M., Yan, Q., Wang, X-R., Song, H-D., Xu, X-N., Wang, J-J., Zhang, X-L., Zhang, X., Wang, Z-Q., Xue, C-L., Brindley, P.J., McManus D.P., Yang, P-Y., Feng Z., Chen, Z. and Han, Z-G. (2006). New perspectives on host parasite interplay by comparative transcriptomic and proteomic analyses of the human blood fluke Schistosoma japonicum. PLOS Pathogens Apr 14;2(4): e29. IF: 8.5

Guo, J., Li, Y.S., Gray, D., Ning, A., Hu, G., Chen, H., Davis, G., Sleigh, A., Feng, Z., McManus, D.P. and Williams, G.M. (2006). A drug-based intervention study on the importance of buffalo for human Schistosoma japonicum infection around Poyang Lake, China. American Journal of Tropical Medicine and Hygiene 74: 335-341. (Corresponding author). IF: 2.5 (Highlighted in Faculty of 1000 Biology).

Zhang, W., Ross, A.G. & McManus, D.P. Mechanisms of immunity in hydatid disease: implications for vaccine development (2008). Journal of Immunology 181:6679-6685. IF: 6.5

Bergquist, R., Utzinger, J. & McManus, D.P. (2008). Trick or treat: the role of vaccines in integrated schistosomiasis Control. PLoS Neglected Tropical Diseases 2(6): e244 doi:10.1371/journal.pntd.0000244

Zhang, W.B., Zhang, Z.Z., Shi, B.X., Li, J., You, H., Tulson, G., Dang, X.S., Song, Y.C., Yimiti, T., Wang, J.C., Jones, M.K. and McManus, D.P. (2006). Vaccination of dogs against Echinococcus granulosus, the cause of cystic hydatid disease in humans. Journal of Infectious Diseases 194: 966-974. . IF: 4.5

Currently Held Grants

Immunopathogenic mechanisms in human schistosomiasis (with Dr Li Yuesheng) 2007-2009 US$440,000 The DANA Foundation (Human Immunology Program)
Transcriptome profiling of the human pathogen Schistosoma japonicum (with Dr Geoffrey Gobert and Prof Paul Brindley) 2007-2009 AUD $312,750 NHMRC project grant (ID 442927)
Transport pathways of host-derived iron in schistosome parasites (with Dr Malcolm Jones and Dr Alexander Loukas) 2007-2009 AUS$309,300 NHMRC project grant (ID 442910)
Immunity and Pathogenesis in Tropical and Infectious Diseases: Implications for Vaccines and Drug Development (with Profs Kemp, Good, Toth, Anstey, Sriprakash, Doolan, Engwerda, Loukas 2008-2012 AUS$15 million NHMRC Programme Grant (ID 496600)