Position

Director, Nossal Institute for Global Health

Contact

Research interests

• Malaria vaccine development
• Cell biology of malaria Cytoadherence and antigenic variation of Plasmodium falciparum
• Field studies of acquisition of immunity to malaria
• Clinical infectious diseases
• Mathematical modelling of infectious diseases
• Global health

Qualifications

MB BS(Melb), FRACP, MPH(Harvard), PhD(Melb), FAFPHM, FACTM

Ten Most Significant Publications

BROWN GV, Anders RF, Mitchell GF and Heywood PF. (1982). Target antigens of purified human immunoglobulins which inhibit growth of Plasmodium falciparum in vitro. Nature 297:591 593.

Biggs, BA, Gooze L, Wycherley K, Wollish W, Southwell B, Leech JH and BROWN GV. (1991). Antigenic variation of Plasmodium falciparum. Proc Natl Acad Sci USA 88:9171 9174.

Biggs BA, Anders RF, Dillon HE, Davern KM, Martin M, Petersen C and BROWN GV. (1992). Adherence of infected erythrocytes to venular endothelium selects for antigenic variants of Plasmodium falciparum. J Immunol 149:2047-2054.

Chaiyaroj SC, Coppel RL, Novakovic S. and BROWN GV. (1994) Multiple ligands for cytoadherence are present on the surface of Plasmodium falciparum infected erythrocytes. Proc Natl Acad Sci USA 91:10805-10808

Rogerson SJ, Chaiyaroj SC, Ng K, Reeder JC and BROWN GV. (1995). Chondroitin sulfate A is a cell surface receptor for Plasmodium falciparum-infected erythrocytes. J Exp Med 182:15-20.

Reeder JC, Cowman AF, Davern KM, Beeson JG, Thompson JK, Rogerson SJ, BROWN GV. (1999). The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P.falciparum erythrocyte membrane protein 1. Proc Natl Acad Sci USA 96:5198-5202.

Beeson JG, Rogerson SJ, Cooke BM, Reeder JC, Chai W, Lawson AM, Molyneux ME, BROWN GV (2000). Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria. Nature Med 6:86-90

Duffy MF, BROWN GV, Basuki W, Krejany EO, Noviyanti R, Cowman AF, Reeder JC. (2002). Transcription of multiple var genes by individual, trophozoite stage Plasmodium falciparum cells expressing a chrondroitin sulfate A binding phenotype. Mol Microbiol. 43:1285-1293.

Genton B, Betuela I, Felger I, Al-Yaman F. Anders RF, Saul A, Rare L, Baisor M, Lorry K, BROWN GV, Pye D, Irving DO, Smith TA, Beck H-P, Alpers MP. (2002) A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a Phase 1-2b trial in Papua New Guinea. J Infect Dis 185: 820-827

Beeson JG, BROWN GV. (2004) Plasmodium falciparum-infected erythrocytes demonstrate dual specificity for adhesion to hyaluronic acid and chondroitin sulfate A and have distinct adhesive properties. J Infect Dis 189: 169-179

Yosaatmadja F, Andrews KT, Duffy MF, Brown GV, Beeson JG, Rogerson SJ. Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line. Malar J. 2008 Mar 26;7:51

Currently Held Grants

2006-2010 Host parasite interactions: Disease, pathogenesis and control. NHMRC Program Grant 406601 Brown (CIB) (in association with AF Cowman, BS Crabb, E Handman, MJ McConville, GI McFadden, L Schofield, TP Speed)

2006- Infrastructure grant, (third stage) Australian Cancer Grid, Department of Innovation, Industry and Regional Development, DIIRD. Consortium of the Molecular Medicine Informatics Model (MMIM)

2007-2012 Intermittent preventive treatment with azithromycin-containing regimens for the prevention of malarial infections and anaemia and the control of sexually transmitted infections in pregnant women in Papua New Guinea. Bill & Melinda Gates Foundation, Global Health Program; European Union Framework Programme 7. Rogerson SJ, Mueller, Siba P, Menendez C. (Co investigators: Beeson J, Brown G, Davis T, Karunajeewa H, Gaita L, Mola G, Zimmerman P.

2008-2010 Transcriptional control of antigenic variation in the malaria parasite Plasmodium falciparum. ARC Discovery Project DP0879293. MF Duffy, GV Brown