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Position
Senior Research Fellow, Eskitis Institute for Cell and Molecular Therapies, Griffith University
Visiting Scientist, Queensland Institute of Medical Research
Executive Officer, Griffith Medical Research College, Griffith University
National Director, Australian Society for Medical Research (ASMR)
Contact
Clinical Tropical Medicine Laboratory (Ban L.11),
Queensland Institute of Medical Research
Po Box Royal Brisbane Hospital, Herston, QLD 4029
Phone: (61) 7 3845 3725
Fax: (61) 7 3362 0104
Email: kathy.andrews@qimr.edu.au
Research interests
Dr Andrews's research focuses on identifying new antimalarial drugs and drug targets. Projects include investigating (i) the antimalarial target of clinically utilized HIV drugs, (ii) histone deacetylase enzymes as new antimalarial targets and dissecting their role in transcriptional regulation, and (iii) development of a molecular interaction platform for antimalarial drug screening and target identification.
Qualifications
2005 GradCert (Educ)
1998 PhD
1992 BSc (Hon)
Ten Most Significant Publications
1. Skinner-Adams TS, McCarthy JS, Gardiner DL & Andrews KT. (2008) HIV and malaria co-infection: Interactions and consequences of chemotherapy. Trends in Parasitology. 24(6): 264-271
2. Andrews KT, Tran TN, Lucke AJ, Kahnberg P, Le GT, Boyle GM, Gardiner DL, Skinner-Adams TS, Fairlie DP. (2008) Potent antimalarial activity of histone deacetylase inhibitor analogues. Antimicrobial Agents and Chemotherapy. 52(4):1454-61
3. Andrews KT, Gatton ML, Skinner-Adams TS, McCarthy JS, Gardiner DL. (2007) HIV-Malaria Interactions: Don't Forget the Drugs. Science (Letter) 315 (5820): 1764-863
4. Andrews KT, DP Fairlie, PK Madala, J Ray, DM Wyatt, PM Hilton, LA Melville, L Beattie, DL Gardiner, RC Reid, MJ Stoermer, T Skinner-Adams, C Berry, and JS McCarthy. (2006) Potencies of HIV protease inhibitors in vitro against P. falciparum and in vivo against murine malaria. Antimicrobial Agents and Chemotherapy 50(2):639-648
5. Andrews KT, Klatt N, Adams Y, Mischnick P, Schwartz-Albiez R. (2005) Inhibition of chondroitin-4-sulfate-specific adhesion of Plasmodium falciparum infected erythrocytes by sulfated polysaccharides. Infection and Immunity 73(7):4288-94
6. Skinner-Adams T, McCarthy JS, Gardiner DL, Hilton P, Andrews KT. (2004) Antiretrovirals as Antimalarial Agents. Journal of Infectious Diseases 190:1998-2000.
7. Andrews KT, Pirrit LA, Przyborski JM, Sanchez CP, Sterkers Y, Ricken S, Wickert H, Lepolard C, Avril M, Scherf A, Gysin J, Lanzer M. Recovery of adhesion to chondroitin-4-sulphate in Plasmodium falciparum varCSA disruption mutants by antigenically similar PfEMP1 variants. (2003) Molecular Microbiology 49(3):655-69
8. Andrews KT, Walduck A, Kelso MJ, Fairlie DP, Saul A, Parsons PG. Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents (2000) International Journal of Parasitology 30(6):761-8
9. Baldi DL, Andrews KT, Waller RF, Roos DS, Howard RF, Crabb BS, Cowman AF. RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum. (2000) EMBO Journal 19(11):2435-43
10. Andrews KT, Wolter LC, Saul A, Hyland CA. The RhD antigen negative trait in a Caucasian with the RhCCee phenotype attributed to a four nucleotide deletion in the RHD gene. (1998) Blood 92(5):1839-40
Currently Held Grants
2007-2009 MMV. R. Quinn, V. Avery, M Good, K Andrews, W Charman, & M Edstein "Lead generation via high-throughput screening of malaria targets against a large natural product extract library."
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