Malcolm McConville
Position
Professor
NHMRC Principal Research Fellow
Head of Bio21 Node, Metabolomics Australia
Address
Department of Biochemistry and Molecular Biology
University of Melbourne
Bio21 Molecular Science and Biotechnology Institute
30 Flemington Rd, Parkville, 3010, Australia
Research interests
My laboratory focuses on identifying new metabolic pathways and network interactions in a number of important human pathogens (including Leishmania sp Plasmodium falciparum and the prokaryotic pathogens, mycobacteria) with the view of identifying novel drug targets, improving our understanding of basic host parasite interactions and developing new markers for diagnosis.
Qualifications
BSc (Hons), PhD
Ten Most Significant Publications
(1) McConville, M. J., Thomas-Oates, J. E., Ferguson, M. A. and Homans, S. W., 'Structure of the lipophosphoglycan from Leishmania major', J. Biol. Chem., 1990, 265, 19611-19623.
(2) McConville, M. J., Turco, S. J., Ferguson, M. A. and Sacks, D. L., 'Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastigotes to an infectious stage', EMBO J., 1992, 11, 3593-3600.
(3) Ilg, T., Overath, P., Ferguson, M. A., Rutherford, T., Campbell, D. G. and McConville, M. J., 'O- and N-glycosylation of the Leishmania mexicana-secreted acid phosphatase. Characterization of a new class of phosphoserine-linked glycans', J. Biol. Chem., 1994, 269, 24073-24081.
(4) Moss, J. M., Reid, G. E., Mullin, K. A., Zawadzki, J. L., Simpson, R. J. and McConville, M. J., 'Characterization of a novel GDP-mannose:Serine-protein mannose-1-phosphotransferase from Leishmania mexicana', J. Biol. Chem., 1999, 274, 6678-6688.
(5) Schofield, L., McConville, M. J., Hansen, D., Campbell, A. S., Fraser-Reid, B., Grusby, M. J. and Tachado, S. D., 'CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells', Science, 1999, 283, 225-229.
(6) Mullin, K. A., Foth, B. J., Ilgoutz, S. C., Callaghan, J. M., Zawadzki, J. L., McFadden, G. I. and McConville, M. J., 'Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana', Mol. Biol. Cell, 2001, 12, 2364-2377.
(7) Ralton, J. E., Naderer, T., Piraino, H. L., Bashtannyk, T. A., Callaghan, J. M. and McConville, M. J., 'Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites', J. Biol. Chem., 2003, 278, 40757-40763.
(8) Dodge, M. A., Waller, R. F., Chow, L. M., Zaman, M. M., Cotton, L. M., McConville, M. J. and Wirth, D. F., 'Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites', Mol. Microbiol., 2004, 51, 1563-1575.
(9) Naderer, T., Ellis, M. A., Sernee, M. F., De Souza, D. P., Curtis, J., Handman, E. and McConville, M. J., 'Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase', Proc. Natl. Acad. Sci. USA, 2006, 103, 5502-5507.
(10) Sernee, F. M., Ralton, J. E., Dinev, Z., Khairallah, G. N., O'Hair, R. A. J., Williams, S. J. and McConville, M. J., 'Biosynthesis of Leishmania mannan is primed by a novel mannose-cyclic phosphate', Proc. Natl. Acad. Sci. USA, 2006, 103, 9458-9463.
Currently Held Grants
Source: NHMRC Principal Research Fellowship (ID# 566643)
Investigator: McConville MJ (sole CI)
Funding period 2009-2013
Source: NHMRC Programme Grant (406601)
Project: Host-parasite interactions: disease, pathogenesis and control.
Coinvestigators Brown, G., Cowman, A., Crabb, B., Handman, E., McFadden, G., Schofield, L. Speed, T. (equal CIs)
Funding period 2006-2010
Source: NHMRC Project Grant (ID# 566644)
Investigators: McConville, MJ (CIA) and Williams, SJ (CIB, Dept Chemistry, University of Melb)
Project: Biosynthesis and function of Leishmania mannogen
Funding period: 2009-2011
Source: ARC/NHMRC Network for Parasitology Grant
Investigators: 60 parasitology research groups within Australia (individual groups apply for funds for travel, conference organization etc as needed)
Funding period: 2004-2008
Source: ARC Discovery Grant
Investigators Williams, S.J (CIA-Dept Chemistry, Melb. Uni), McConville, MJ (CIB)
Project: Chemical tools for the study of the biosynthesis of PI mannosides in Mycobacteria.
Funding period: 2007-2009
Source: ARC Discovery Grant
Investigators Likic, V (CIA) and McConville, MJ (CIB)
Project: Characterization of metabolic networks in a microbial pathogen
Funding period: 2008-2010
|
