Associate Professor Peter Upcroft

Position

Principal Research Fellow

Address

Queensland Institute of Medical Research
Royal Brisbane Hospital Post Office
Herston, Queensland, 4029

Research interests

Giardia duodenalis, Entamoeba histolytica, Trichomonas vaginalis, drug resistance, new drugs, genome organisation.

Qualifications

PhD, '75

Ten Most Significant Publications

Upcroft P, Upcroft JA, Skolnik H, Fareed GC. 1977. Episomal states of an SV40‑Escherichia coli recombinant genome in different mammalian cell lines. In: Molecular Approaches to Eucaryotic Genetic Systems. Wilcox G, Abelson J, Fox CF, eds. Academic Press, New York. pp. 141-151.

Upcroft P, Skolnik H, Upcroft JA, Solomon D, Khoury G, Hamer DH, Fareed GC. 1978. Transduction of a bacterial gene into mammalian cells. Proc Nat Acad Sci US 75: 2117-2121.

Brown D, Upcroft JA, Upcroft P. 1993. Cysteine is the major low molecular weight thiol in Giardia. Mol Biochem Parasitol 61: 155-158.

Townson SM, Upcroft JA, Upcroft P. 1996. Characterisation and purification of pyruvate: ferredoxin oxidoreductase from Giardia duodenalis. Mol Biochem Parasitol 79: 183-193.

Brown DM, Upcroft JA, Upcroft P. 1996. A H2O-producing NADH oxidase from the protozoan parasite Giardia duodenalis. Eur J Biochem 241: 155-161.

Upcroft JA, Mitchell R, Chen N, Upcroft P. 1996. Albendazole resistance in Giardia is correlated with cytoskeletal changes but not with a mutation at amino acid 200 in -tubulin.  Microb Drug Resis 2: 303-308.

Upcroft P, Chen N, Upcroft JA. 1997. Telomeric organization of a variable and inducible toxin gene family in the ancient eukaryote Giardia duodenalis. Genome Res 7: 37-46.

Upcroft JA, McDonnell PA, Upcroft P. 1997. Lethal Giardia from a wild caught sulphur-crested cockatoo (Cacatua galerita) established in vitro chronically infects mice. Parasitology 114: 407-412.

Upcroft P, Upcroft JA. 2001. Drug treatment and drug resistance in the anaerobic protozoa.
Clin Microbiol Rev 14: 150-164.

Upcroft J, Upcroft P. 2001. Drug susceptibility testing of the anaerobic protozoa. Antimicrob Agents Chemother 45: 1810-1814.