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Position
NH&MRC Australian Biomedical Fellow
Contact
Biochemistry and Molecular Biology
School of Biology
Building 41
Australian National University
Canberra ACT 0200
E: Rowena.Martin@anu.edu.au
T: (+61 2) 6125 8589
F: (+61 2) 6125 0313
W: http://www.anu.edu.au/bambi/people/academic/rmartin.php
and
School of Botany
Building 122
University of Melbourne
Parkville VIC 3010 AUSTRALIA
Research interests
Research in my group is focused primarily on understanding mechanisms of drug resistance in malaria parasites. We have a particular interest in those membrane transport proteins implicated in mediating the efflux of antimalarial compounds from drug-resistant parasites. Our work involves a combination of approaches, including molecular, biochemical, pharmacological, and bioinformatic techniques.
Qualifications
BSc Hons (ANU)
PhD (ANU)
Ten Most Significant Publications
Martin RE and Kirk K. (2007) Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Blood, 109: 2217-24
Henry RI, Martin RE, Howitt SM, and Kirk K. (2007) Localisation of a candidate anion transporter to the surface of the malaria parasite. Biochem. Biophys. Res. Commun., 363: 288-291
*Saliba KJ, *Martin RE, Bröer A, Henry RI, McCarthy CS, Downie MJ, Allen RJW, Mullin KA, McFadden GI, +Bröer S and +Kirk K. (2006) Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature 443, 582-585 [*+ Equal contributions]
Martin RE, Henry RI, Abbey JL, Clements JD, and Kirk K. (2005) The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum. Genome Biol. 6, R26
*Bray PG, *Martin RE, Tilley L, Ward SA, Kirk K, and Fidock DA. (2005) Defining the role of PfCRT in P. falciparum chloroquine resistance. Mol. Microbiol., 56: 323-33 [* Joint first authors]
Kirk K, Martin RE, Bröer S, Howitt SM, and Saliba KJ. (2005) Plasmodium Permeomics: Membrane transport proteins in the malaria parasite. Curr. Top. Microbiol. Immunol.: Malaria (S Krishna and D Sullivan, eds), 295: 325-56
Martin RE and Kirk K. (2004) The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily. Mol. Biol. Evol., 21: 1938-49
Clements JD and Martin RE. (2002) Identification of novel membrane proteins by searching for patterns in hydropathy profiles. Eur. J. Biochem., 269: 2101 -07
Saliba KJ, Martin RE, Staines HM, and Kirk K. (1999) A novel anion channel in the malaria-infected erythrocyte: opportunities for antimalarial chemotherapy, in Chloride Channels (RZ Kozlowski, ed) Isis Medical Media, pp 137-48
Kirk K, Staines HM, Martin RE, and Saliba KJ. (1999) Transport properties of the host cell membrane, in Transport and Trafficking in the Malaria-Infected Erythrocyte, Wiley, Chichester (Novartis Foundation Symposium 226) pp 55-73
Currently Held Grants
NH&MRC Project Grant 471472: Martin, R. E. 2008-2010 for the Project 'Characterization of the chloroquine resistance transporter of the malaria parasite'.
NH&MRC Australian Biomedical Fellowship 520320: Martin, R.E. - for the project 'Trafficking of the malaria parasite's chloroquine resistance transporter'.
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