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Professor Simon Foote

Position

Director, Menzies Research Institute

Address

Menzies Research Institute
Private Bag 23
Hobart  Tasmania  7001
Tel: (03) 6226 7702
Web: www.menzies.utas.edu.au

Research interests

I have several research interests. In genetics, my research includes the genetics of cancer, familial diseases such as multiple sclerosis and epilepsy. Another research interest is parasitology, my malarial research interests include creating new and novel drugs for treatment of malaria and the physiological response to malaria.

Qualifications

1982 BMedSci, Department of Physiology, University of Melbourne

1984 MBBS, University of Melbourne

1990 PhD, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne

Ten Most Significant Publications

1. Panthier J, FOOTE S, Chambraud B, Strosberg A, Corvol P, Rougeon F. (1982) Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor . Nature 298, 90-92.

2. Cowman AF, Morry M.J., Biggs BA, Cross GAM, FOOTE SJ. (1988) Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 85, 9109-9113.

3. FOOTE SJ, Thompson JL, Cowman AF, Kemp DJ. (1989) Amplification of the mdr gene in some chloroquine resistant isolates of Plasmodium falciparum. Cell 57, 921-930.

4. FOOTE SJ, Kyle DE, Martin RK, Oduola AM, Forsyth K, Kemp DJ and Cowman AF. (1990) Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in P. falciparum. Nature 345, 255-258

5. Vollrath D, FOOTE SJ, Hilton A, Brown LG, Beer-Romero P, Bogan JS, Page DC. (1992) The human Y chromosome: A 43-interval map based on naturally occurring deletions. Science 25, 52-59

6. FOOTE SJ, Vollrath D, Hilton A, Page DC. (1992) The human Y chromosome: Overlapping DNA clones spanning the euchromatic region. Science 258, 60-66

7. Hudson TJ, Stein L, Gerety S, Ma J, Silva J, Castle A, Silva J, Slonim D, Baptista R, Kruglyak L, Xu SH, Hu Z, Colbert A, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Wu X, Vestergaard C, Wilson K, Bae J, Maitra S, Ganiatsis S, Evans C, DeAngelis MM, Ingalls K, Nahf R, Horton L, Anderson M, Collymore A, Ye WJ, Kouyoumjian V, Zemsteva I, Tam J, Devine R, Courtney D, Renaud M, Nguyen H, O'Connor T, Fizames C, Faure S, Gyapay G, Dib C, Morissette J, Orlin JB, Birren BW, Goodman N, Weissenbach J, Hawkins T, FOOTE SJ, Page DC, Lander ES. (1995) An STS-based map of the human genome. Science 270:1945-1954

8. FOOTE SJ, Burt RA, Baldwin TM, Presente A, Roberts AW, Laural YL, Lew AM, Marshall VM. (1997) Mouse Loci for malaria-induced mortality and the control of parasitaemia. Nature Genetics 17:380-381

9. Symons RCA, Daly MJ, Fridlyand J, Speed TP, Cook WD, Gerondakis S, Harris AW, FOOTE SJ. (2002) Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E-v abltransgenic mice Proc Natl Acad Sci Aug 20;99(17):4750-3.

10. Sakthianandeswaren A, Elso CM, Simpson K,Curtis JM, Kumar B, Speed TP, Handman E, FOOTE SJ. (2005). "The wound repair response controls outcome to cutaneous leishmaniasis." Proc Natl Acad Sci U S A. 102, 15551-6

Currently Held Grants

NHMRC Program Grant #490037: Genetic and Bioinformatic Analysis of Complex Human Diseases

NHMRC 406640: Identifying target genes for novel anti-epileptic therapies in the mouse.

ARC Linkage: Identifying Genes that influence clinical course and susceptibility in multiple sclerosis.

ARCF: The ACRF Tasmanian Inherited Cancer Centre

ARC Linkage Infrastructure: Establishment of a confocal/multiphoton microscope for imaging of living systems.

Howard Hughes Medical Institute: Infectious Diseases and parasitology - International Research Scholars Program

Department of Education, Science and Training, National Collaborative research Infrastructure Strategy. Animal models of disease 5.2.1 - The Australian Phenomics network

Tasmanian Community Fund: Tasmanian community network of mentors and smart information techonolgy solutions (SITS) for families affected by cystic fibrosis

University of Tasmania: Preseed Funding Grant

GalaxoSmithKline: Postgraduate Student Support