Position

Emeritus Professor

Contact

Department of Biochemistry
La Trobe University,
VIC 3086 AUSTRALIA

Tel: 61-3-9479 2802
Mobile: 0402344511
Fax: 61-3-9479 2467
Email: R.Anders@latrobe.edu.au
www.latrobe.edu.au/biochemistry/lab/anders/index.htm

Research interests

Malaria vaccine development with a particular focus on asexual blood stage antigens of Plasmodium falciparum.

Structure and function of malaria merozoite surface proteins.

Qualifications

PhD, B.Agr.Sc

Ten Most Significant Publications

Kemp DJ, Coppel RL, Cowman AF, Saint RB, Brown GV and ANDERS RF. (1983). Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans. Proc. Natl. Acad. Sci. USA. 80: 3787-3791.

Coppel RL, Cowman AF, Lingelbach KR, Brown GV, Saint RB, Kemp DJ and ANDERS RF. (1983). Isolate-specific S antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids. Nature 306: 751-756.

Cowman AF, Saint RB, Coppel RL, Brown GV, ANDERS RF and Kemp DJ. (1985). Conserved sequences flank variable tandem repeats in two S-antigen genes of Plasmodium falciparum. Cell 40: 775-783.

Brown GV, Culvenor JG, Crewther PE, Bianco AE, Coppel RL, Saint RB, Stahl HD, Kemp DJ and ANDERS RF. (1985). Localization of the ring-infected erythrocyte surface antigen (RESA) of Plasmodium falciparum in merozoites and ring-infected erythrocytes. J. Exp. Med. 162: 774-779.

Smythe JA, Coppel RL, Brown GV, Ramasamy R, Kemp DJ and ANDERS RF. (1988). Identification of two integral membrane proteins of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA. 85: 5195-5199.

Hodder AN, Crewther PE, Matthew MLSM, Reid GE, Moritz RL, Simpson RJ and ANDERS RF. (1996) The disulfide bond structure of Plasmodium apical membrane antigen 1. J. Biol. Chem. 271: 29446-29452.

ANDERS RF, Crewther PE, Edwards S, Margetts M, Matthew MLSM, Pollock B and Pye D. (1998). Immunization with recombinant AMA-1 protects mice against infection with Plasmodium chabaudi. Vaccine 16: 240-247.

Genton B, Betuela I, Felger I, Al-Yaman F, ANDERS RF, Saul A, Rare L, Baisor M, Lorry K, Brown GV, Pye D, Irving DO, Smith TA, Beck HP and Alpers MP. (2002) A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea. J. Infect. Dis. 185:820-827.

Bai T, Becker M, Gupta A, Strike P, Murphy VJ, ANDERS RF and Batchelor AH. (2005) Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket. Proc. Natl. Acad. Sci. USA 102:12736-41.

Coley AM, Gupta A, Murphy VJ, Bai T, Kim H, Foley M, ANDERS RF and Batchelor AH. (2007) Structure of the malaria antigen AMA1 in complex with a growth-inhibitory antibody. PLoS Pathog. 3:1308-19.

Currently Held Grants

NIH (USA) Inhibitory epitopes in malaria vaccine candidates. A/Prof. Foley, Prof. Norton, & Prof. Anders 2006-2010 (RO1 AI059229-01A1)